Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex.
نویسندگان
چکیده
Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50-300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocortical ACh release. Ethanol apparently acts on cholinergic fibers to modulate ACh transmission in the PFC. These results could be of relevance for the bidirectional modulation of working memory by ethanol.
منابع مشابه
Effects of systemic and intra-prefrontal cortex administrations of ethanol on spatial working memory in male rats
Introduction: Ethanol can induce a wide spectrum of neurophysiological effects via interaction with multiple neurotransmitter systems and disruption of the balances between inhibitory and excitatory neurotransmitters. Prefrontal cortex is involved in cognitive process including working memory and is sensitive to ethanol. Present study investigates the effects of intraperitoneal (i.p.) admini...
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متن کاملHistochemical Evaluation of the Activities of Vitamin C on Ethanol Administration in Rat; Implication on the Cytoarchitectural and Some Neurochemical Indices of the Prefrontal Cortex
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متن کاملHistochemical Evaluation of the Activities of Vitamin C on Ethanol Administration in Rat; Implication on the Cytoarchitectural and Some Neurochemical Indices of the Prefrontal Cortex
Objective: This study was to evaluate the effect of Vitamin C on the histology and histochemistry of the prefrontal cortex of ethanol-induced rats. Methods: Male Sprague-Dawley rats were used for the study. Ethical approval was obtained from the University’s ethical committee. The rats were randomly divided into 6 groups of 10 rats each. Rats in group A= free access to normal saline. Rats in gr...
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ورودعنوان ژورنال:
- Brain research
دوره 997 1 شماره
صفحات -
تاریخ انتشار 2004